Wolverhampton Wanderers hit Manchester United's top-four hopes with a 2-1 comeback victory at Molineux.
Ole Gunnar Solskjaer's side were rewarded for early pressure with a goal on 13 minutes.
Fred fed Scott McTominay, who directed a long-range effort into the corner for his first PL goal.
But 12 minutes later, Wolves were level. Fred lost the ball, allowing Raul Jimenez to send through Diogo Jota, who struck past David De Gea.
Rui Patricio kept out McTominay's close-range header before United's Ashley Young was sent off for a second yellow card.
Wolves claimed the three points with 13 minutes left when United's Chris Smalling deflected the ball past De Gea.
Man Utd stay in fifth on 61 points, two behind Arsenal in third, having played a match more. Wolves remain seventh on 47 points.