According to the Fixture Difficulty Ratings (FDR), three of their remaining five matches score only two.
The fitness of Harry Kane (£11.8m) will determine how managers plan for the run-in.
He overcame an ankle injury to start in Spurs' EFL Cup final against Manchester City on Sunday.
Kane is just behind Bruno Fernandes (£11.6m) at the top of the player standings in Fantasy. He is also one goal ahead of Mohamed Salah (£12.6m) in the race for the Golden Boot.
Son Heung-min (£9.5m) and Gareth Bale (£9.1m) also look set to enjoy a successful run-in.
Son played up front and was also on penalty duties in Kane’s absence against Southampton in midweek.
If Kane is not able to play for a period, Son's potential for explosive hauls at home can help managers' captaincy decisions.
Seven of his last eight double-figure hauls have come at Tottenham Hotspur Stadium.
Bale could prove a big differential in Fantasy, having returned to Spurs' starting XI in the first match of the post-Jose Mourinho area.
Owned by only 3.1 per cent of FPL managers, the Welshman has five goals, an assist and 45 points in his last five starts.
In defence, five assists and six clean sheets highlight the all-round appeal of Sergio Reguilon (£5.6m).
Part 2: GW33 Bonus points: Wan-Bissaka delivers a maximum
Part 3: GW33 FPL stats: Salah on target as top captain pick
Part 4: FPL Saturday review: Rudiger the best value at Chelsea
Part 5: GW33 Lessons: Climb mini-leagues with players battling drop
Part 6: GW33 Lessons: Dallas vital for the run-in
Part 7: Who to target from clubs seeking safety? What the experts say