They will also be without head coach Jose Mourinho, who has been relieved of his duties after 17 months in charge.
As the top-scoring player in Fantasy, Kane’s owners will clearly be reluctant to sell the forward.
But they must now await an update on his fitness after he was forced off towards the end of Friday's 2-2 draw at Everton.
If Kane is available to face Southampton in the second match of Spurs’ Double Gameweek 32, most managers will simply bench him for Gameweek 33.
His form, combined with his battle with Mohamed Salah (£12.5m) for the Golden Boot, means that selling Kane would be a very risky decision.
He also has a strong schedule and can thrive as a major captaincy pick over the run-in, with only one of Spurs’ final five matches scoring more than three in the Fixture Difficulty Ratings (FDR).
|34||SHU (H)||2||37||AVL (H)||2|
|35||LEE (A)||3||38||LEI (A)||4|
But if there is confirmation that Kane injured, his absence will force managers to reassess their plans for the final Gameweeks.
Those holding Son may have a more straightforward decision.
The South Korean has scored just two goals, and supplied four assists, from Gameweek 18 onwards.
By comparison, Kane has 11 goals and two assists in that period, bettering Son by 93 points to 57.
Swapping out Son for another midfield big-hitter such as Salah could appeal, while Jesse Lingard (£6.6m), Christian Pulisic (£8.3m) and Mason Greenwood (£7.0m) also boast strong form as more budget-friendly options.
Part 1: FDR Analysis: Brighton can provide short-term value
Part 2: FPL team news: Calvert-Lewin back for Everton
Part 3: GW32 Bonus points: Evans shines for Leicester
Part 4: GW32 FPL stats: Double disappointment for Salah backers
Part 5: FPL Saturday review: Lingard rush continues
Part 7: FPL experts: What to do with Son and Kane
Part 8: GW32 Monday review: Alexander-Arnold on form