Adrian Clarke is looking at key tactical talking points ahead of Matchweek 13.
From only two starts and 220 minutes of a stop-start debut Premier League season, the 21-year-old has scored two spectacular, match-winning goals.
The Mali international announced his arrival with a long-range drive into the top corner to open the scoring in a 2-0 victory at Brighton & Hove Albion.
A muscular injury kept Djenepo out of action until early November, when he returned with a six-minute cameo as a substitute in the 2-1 defeat at Manchester City.
And after completing 90 minutes in the Matchweek 12 loss to Everton, and scoring against Chad during the international break, he should be fully fit and raring to go on Saturday when Saints travel to Arsenal.
Manager Ralph Hasenhuttl has missed the cutting edge of a player who has scored Saints' only two winning goals of the season to date.
Against Sheffield United, the Austrian initially experimented by using Djenepo as a left wing-back.
But after 30 minutes, it was clear the summer signing was struggling with his defensive positioning and had become a target for the Blades.
Once moved into a more familiar attacking midfield berth, the former Standard Liege man was a revelation.
Using his power, pace and nimble footwork to torment defenders, he completed an impressive six successful dribbles.
Most of those runs were in dangerous areas around the penalty area and one of them produced the winner.
Arsenal will be wary of Djenepo's threat at Emirates Stadium on Saturday.
While the Gunners are unbeaten at home to Southampton in 24 league matches stretching back to 1987, Unai Emery's side have not won in the Premier League since Matchweek 8.
And seven of the eight points that Saints have won this season have come on the road.
So Arsenal will need their midfielders to get tight on Djenepo whenever he drives inside at speed, working hard to crowd him out.
Emery has a decision over whom to start at right-back. Hector Bellerin is back fit but has made only one start all season, so Djenepo could exploit any lack of match sharpness.
If the winger is given the room to isolate individuals one-v-one, he has shown he has the skill to transform a contest with a moment of brilliance.
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Djenepo scored eight times in 24 starts in last season's Belgian Jupiler League, at a rate of one goal every 258 minutes.
It was a respectable return for the winger, who ended the campaign with a conversion rate of 17.4 per cent.
At Southampton, he has scored a goal every 110 minutes and has a 40 per cent shot-conversion rate.
That level will be impossible to maintain. But Djenepo's right foot looks like it can be a destructive weapon this season.
Hasenhuttl has plenty of options in forward areas.
But do not be surprised if Djenepo is deployed as a second striker in the coming weeks, playing just behind the centre-forward.
His speed, balance and trickery will frighten defenders in the centre of the pitch and his finishing looks excellent.
Part 1: Palace adventure against Liverpool can work wonders
Part 3: Mourinho must solve pressing issue for fast Spurs start
Part 4: Angelino a two-way target for Man City and Chelsea
Part 5: Martial can make the difference at Sheff Utd