Jota has been a reliable source of returns when starting at Anfield recently, scoring three goals and collecting 22 points in his last two home starts.
The underlying numbers further highlight his major goal threat of late.
His 14 shots inside the box are joint-top with Salah over the last four Gameweeks, while his seven big chances were a league-leading total.
That earns Jota a place in a 3-5-2 formation and the vice-captaincy, with Salah handed the armband.
The Crystal Palace goalkeeper has been more reliable at home this season, earning three of his four clean sheets at Selhurst Park. Guaita faces a Southampton side who have scored only three goals in their last six away matches.
Five double-figure hauls in 14 appearances underline his explosive potential. The right-back has 33 points across his last three matches at Anfield, combining three assists with three clean sheets and six bonus points.
The Ukrainian helped Manchester City to their ninth clean sheet of the season last weekend against Wolverhampton Wanderers. Zinchenko offers a value route into Pep Guardiola’s defence while Joao Cancelo (£6.8m) serves a one-match ban.
Brighton & Hove Albion’s right-back offers points potential at both ends of the pitch at home to Wolves. Lamptey’s seven chances created in the last four Gameweeks rank third among defenders in Fantasy.
Liverpool’s Egyptian has scored in all four of his home meetings with Newcastle, claiming 38 points. Facing a defence who conceded four goals at Leicester City last weekend, Salah will again be the runaway captain favourite for managers in Gameweek 17.
Jota's average of 130.3 minutes per goal this season places third among midfielders in Fantasy who have scored more than twice.
Owned by only 5.9 per cent of managers, the midfielder could prove a huge differential against a Leeds side with one away clean sheet all season. Foden looks set to return to the Man City starting XI after coming off the bench last weekend.
The midfielder has been Chelsea's standout performer in Fantasy ahead of their home match against Everton. Mount has scored in three successive Gameweeks and also supplied two assists, totalling 31 points.
Sterling has scored in back-to-back Gameweeks, claiming 18 points across matches against Watford and Wolves.
Watford's forward has averaged 6.3 points per away match under Claudio Ranieri ahead of a trip to Burnley. King's total of 10 big chances since the Italian took charge is joint-top among all players in Fantasy along with Salah and Jota.
Part 1: GW17 Kings to watch: Foden fresh to shine against Leeds
Part 2: GW17 Differentials: Lacazette can extend West Ham streak
Part 3: GW17 Captains: Man City stars can rival Salah
Part 5: Who are the best Ronaldo and Fernandes replacements?
Remember, the Gameweek 17 deadline is now at 18:15 GMT on Tuesday 14 December.