Cristiano Ronaldo (£12.5m) and Bruno Fernandes (£11.6m) are owned by 32.6 per cent and 16.0 per cent of managers respectively ahead of Tuesday’s 18:15 GMT deadline.
But both players now blank in Gameweek 17 due to an ongoing COVID-19 outbreak within Man Utd's squad.
Certainly, those looking to transfer out their Red Devils’ assets should be aware they have one of the most favourable winter schedules of any side.
With that in mind, Ronaldo owners, in particular, should focus on short-term replacements.
Joshua King (WAT) £5.8m
Watford’s striker has scored all five of his goals this season in his eight appearances under Claudio Ranieri.
Ollie Watkins (AVL) £7.6m
The Aston Villa forward has stepped up his output since the arrival of Steven Gerrard.
Watkins has scored two of his four goals this season in the new head coach’s five matches in charge.
According to the FDR, four of Villa’s next five matches score only two. He faces Norwich City and Burnley next.
The Gunners’ subsequent two matches, against Leeds United and Norwich, score only two in the FDR.
Conor Gallagher (CRY) £6.2m
Crystal Palace’s midfielder is the third top-scoring player in his position on 87 points, thanks to six goals and five assists.
Gallagher’s total of four double-figure hauls highlights his explosive potential ahead of a kind run of opponents, with three of the Eagles’ next four matches, including contests with Southampton and Watford in the next two Gameweeks, scoring two in the FDR.
Jarrod Bowen (WHU) £6.5m
Owned by just 7.3 per cent, the West Ham winger has produced returns in seven of his last 11 starts.
Bowen looks set to thrive as a major differential over the winter, with four of the Hammers’ next five matches scoring two in the FDR.
A trip to Arsenal in Gameweek 17 is followed by a home encounter with Norwich.
Jota’s 14 shots inside the box were joint-top with Mohamed Salah (£13.1m) in Fantasy over the last four Gameweeks, while his seven big chances were a league-leading total.
In Gameweek 18, Jota will come up against Tottenham Hotspur.
Whereas Bernardo Silva (£7.7m) is found in 31.3 per cent of squads, Foden and Sterling are owned by 5.9 and 1.8 per cent respectively.
Foden was rested at the weekend and could start both those upcoming encounters, while Sterling has three goals, an assist and 34 points in the last five Gameweeks.
Part 1: GW17 Kings to watch: Foden fresh to shine against Leeds
Part 2: GW17 Differentials: Lacazette can extend West Ham streak
Part 3: GW17 Captains: Man City stars can rival Salah
Part 4: Scout Selection: Jota leads Liverpool triple-up
Remember, the Gameweek 17 deadline is now at 18:15 GMT on Tuesday 14 December.