Thomas Tuchel’s side are flying high thanks, in part, to their strong defensive record.
They have conceded just two goals in the first six Gameweeks, a Mohamed Salah (£12.6m) penalty and a deflected effort by Gabriel Jesus (£8.6m).
Chelsea’s next five Gameweeks
According to the Fixture Difficulty Ratings (FDR), each of Chelsea's next five matches score just two.
While that suggests they can continue to deliver clean sheets, Tuchel's rotation policy at the back raises the risk of players being benched on occasion.
Marcos Alonso (£5.8m) and Antonio Rudiger (£5.6m) are the only defenders to have started the first six Gameweeks for the Blues.
Both have combined one goal with four clean sheets, with Alonso also supplying an assist.
However, Ben Chilwell (£5.6m) is expected to soon compete with Alonso for the left wing-back role after earning his first start of 2021/22 in the EFL Cup in midweek.
Rudiger scores v Spurs
Goalkeeper Edouard Mendy (£6.0m) and Cesar Azpilicueta (£6.0m) are perhaps the better long-term picks.
Mendy's multiple routes to returns could appeal to those looking for a premium-priced No 1.
In addition to his three shutouts, the Senegalese has produced five save points and two bonus points in his five appearances.
Azpilicueta has started more matches than any other Chelsea player since Tuchel arrived as head coach midway through last season.
Lukaku the key target
In attack, Romelu Lukaku (£11.6m) is the standout pick by some margin.
The Belgian has played from start to finish in all five Gameweeks since re-joining the club.
Lukaku's tally of four goals from six appearances across all competitions shows why he will be a key captaincy pick over the coming period.
Midfielders Kai Havertz (£8.2m) and Mason Mount (£7.4m) are capable of bringing in big hauls but their acquisition comes with a risk attached, as both are far more likely to be rotated than Lukaku.
Also in this series
Remember, the Gameweek 7 deadline is at 11:00 BST on Saturday 2 October.