Adrian Clarke looks at key tactical points in Matchweek 11.
The central midfield has struggled to contain opponents without him across the last two-and-a-half matches.
While Partey's absence is not the sole reason for Arsenal's frailties, it is impossible to ignore how much his protection of the defence has been missed.
|With Partey||Without Partey|
|Shots faced||18||Shots faced||46|
|Shots faced on target||4||Shots faced on target||15|
The stats above tell a very clear story.
Only Liverpool have created more big chances than the 29 of table-topping Spurs, who can take advantage of Arsenal's soft centre.
A poor performance at home against Villa prompted Arteta to switch from a 3-4-2-1 to a 4-2-3-1 formation in both Matchweeks 9 and 10.
However, the structure of their build-up play in this shape left them more susceptible to turnovers.
Xhaka often drops deep to start moves, Ceballos shifts across to a right-back spot, and Hector Bellerin pushes on to join the attack.
Arsenal build their passages of play inside the opposition half in a 3-2-5 on a regular basis.
The downside is that when play breaks down, it can leave them open in the middle.
If Arteta persists with this tactical approach, Son Heung-min has the potential to cause huge problems.
After recovering from contracting COVID-19, Mohamed Elneny could make a return to Arsenal's starting XI
The Egyptian was outstanding in the 1-0 win at Manchester United and provides physicality in midfield.
Arteta could use him and move to a 4-3-3 in a bid to match up with Spurs, screening service into Jose Mourinho's dangerous front three.
The alternative would be to revert back to 3-4-2-1, a formation that helped Arsenal win last season's FA Cup and emerge victorious at Old Trafford.
In many respects a back three makes sense for this derby.
The Brazilian, who kept Marcus Rashford exceptionally quiet in the victory at Man Utd, will be of paramount importance.
A number of big decisions lie ahead for Arteta as he prepares to get his side's campaign back on track.
If he makes the right ones, Arsenal can put an early dent in Spurs' title charge and restore some much-needed confidence.