The Brighton & Hove Albion striker won 6-1 on the EA SPORTS FIFA 20 game, with the Frenchman playing a starring role as himself.
"That's me finished on FIFA now - I'm not playing again!" McGinn joked.
Day 1 results
John McGinn (AVL) 1-6 Neal Maupay (BHA)
Josh Franceschi (ARS) 4-3 Nathaniel Chalobah (WAT) | Report
Dwight McNeil (BUR) 3-2 Ryan Fredericks (WHU) | Report
Philip Billing (BOU) 4-0 Angus Gunn (SOU) | Report
Prize fund to NHS
The prize fund is being donated to the #PlayersTogether initiative, created by Premier League players as a collective way of generating funds for the National Health Service and distributing them where they are needed most.
The tournament will also continue to urge everyone to follow official advice by staying home and saving lives.