Will his team sit back and view a point as a decent return, like they did earlier this month at Anfield?
Or will the hosts opt to take the fight to a Tottenham Hotspur side who arrive in wonderful form?
To achieve a positive result, the answer will almost certainly lie somewhere in between.
A 1-0 success for Man Utd in last season’s corresponding fixture is a good indicator of the strategy that may work best.
That day the hosts were happy to let Mauricio Pochettino’s men have 59.9% possession and drop off inside their own half.
This ploy denied Spurs’ forwards space. Forced to play in front of them, the north Londoners were limited to just three efforts on goal from inside the area.
Defending was not Man Utd’s sole focus though.
So even though they adopted tight, counter-attacking tactics, the defensive players did not have to hold firm under spells of relentless pressure. Indeed, Mourinho’s men spent slightly longer inside their attacking third than they did at the other end.
The balance was spot on.
Much like their last meeting at Old Trafford, part of the gameplan will be to deny Spurs’ full-backs the room to make a difference.
Chelsea used a similar ploy at Wembley Stadium earlier this season, successfully negating the influence of the full-backs.
This tactic forced Spurs’ wide men to sling crosses into the box from deep, or move infield where there was congestion.
As shown in the graphic below, on Spurs’ last visit United broke up a stream of attacks in the wide channels.
With this in mind don’t be surprised if Mourinho reverts to a three-man central midfield on Saturday.
From a tactical perspective Mourinho has plenty to ponder ahead of kick-off.
Sitting deep for 90 minutes and playing for a draw is not acceptable on home turf, but don’t be surprised if the Portuguese comes up with a plan designed to stop Spurs in their tracks.
He may even consider trying to match them up in a 3-1-4-2.
Whatever system he chooses, this is a match the hosts should be looking to win, despite Spurs’ outstanding form.
If they are to contend for this season’s Premier League title United must take three points off some of their main rivals, so these home encounters will be critical to their prospects.
On the back of a chastening loss to Huddersfield Town, I expect a purposeful and positive response.