The Tottenham Hotspur forward has an outstanding record against the Foxes, producing 16 goals and four assists in 13 appearances.
Kane has averaged 9.2 points per match in those meetings, delivering double-digit hauls in three of the last four.
His team-mate Son Heung-min (£11.0m) boasts an impressive record at home this season, with six of his eight double-figure returns coming at Tottenham Hotspur Stadium.
However, it is Mohamed Salah (£13.3m) who is likely to be the most-selected captain as Liverpool visit Newcastle United on Saturday.
Away from home, the Egyptian’s 11 goals and 20 big chances are both more than any other player in Fantasy.
Salah has averaged 8.6 points per match on the road, blanking in only three of his 14 starts.
Liverpool full-backs Trent Alexander-Arnold (£8.4m) and Andrew Robertson (£7.3m) provide further armband options.
They have produced eight and six double-digit returns respectively in 2021/22 Fantasy.
Pep Guardiola’s side won 7-0 against Leeds in Gameweek 17, with De Bruyne claiming 16 points.
Sterling, meanwhile, has amassed 32 points in his last three road trips.
Finally, Cristiano Ronaldo (£12.2m) and Philippe Coutinho (£7.0m) both have the home form to bring in big returns.
Coutinho has averaged seven points per home start ahead of Aston Villa's encounter with bottom-of-the-table Norwich City.