Mohamed Salah (£13.2m) and Kevin De Bruyne (£11.8m) have the form and fixture to outscore players who have two matches in Gameweek 34 of Fantasy Premier League.
The Egyptian produced 15 points in his previous meeting with his Merseyside rivals in Gameweek 14.
The Belgian has recorded five of his six double-figure hauls this season at the Etihad Stadium.
Sadio Mane (£11.7m) and Riyad Mahrez (£8.6m) offer in-form alternatives to their more expensive team-mates.
Mane has recorded 47 points in his last four home starts, while Mahrez has produced double-figures in each of his last five home starts.
Chelsea and Man Utd are the only two sides who are scheduled to play twice.
Mason Mount (£7.7m), Kai Havertz (£7.9m) and Cristiano Ronaldo (£12.2m) are the in-form picks from the DGW34 sides.
Chelsea's Mount has four goals and three assists in his last four outings in all competitions, while his team-mate Havertz has scored five of his seven goals this season in his last six matches.
Ronaldo, meanwhile, has scored a hat-trick and earned 17 points in two of his last three appearances for Man Utd.
Kane has blanked just once in his last eight matches, earning 67 points thanks to five goals and eight assists.
Son has returned double-figures in three of his previous four, including his season-high 21 points at Aston Villa in his last road trip.