Mohamed Salah (£13.0m) has been the go-to captain for millions of managers each Gameweek in Fantasy.
Antonio is the Hammers’ most popular player, selected by 36.5 per cent.
After a run of blanks, he has returned to form with a goal and an assist over the last two Gameweeks.
The forward delivered an 11-point haul against the Eagles in Gameweek 3.
Bowen, meanwhile, approaches the Double on the back of his season-high haul of 14 points against Watford last midweek.
The midfielder has been involved in 14 goals this term, already matching his total from the previous campaign.
His 28 shots in the box and 19 chances created both team-leading totals for the Bees.
He scored in each of the first three Gameweeks, claiming 23 points before being sidelined.
While Double Gameweek players are likely to dominate managers’ captaincy decisions, Tottenham Hotspur duo Harry Kane (£12.2m) and Son Heung-min (£10.5m), along with Cristiano Ronaldo (£12.5m) of Manchester United, are among the best options with just one fixture.
Kane has scored in three successive appearances for the first time this season ahead of Spurs’ trip to Watford.
The Hornets are the only side yet to keep a clean sheet in 2021/22.
Meanwhile, Son has produced attacking points in each of his last five, totalling 42 points thanks to four goals and two assists.
Ronaldo has double-figure hauls in two of his last three home matches ahead of a visit from Wolverhampton Wanderers.
Part 1: GW21 Kings to watch: De Bruyne back to his best
Part 2: GW21 Differentials: Lucas fresh for Watford trip
Part 4: Scout Selection: Gray tipped for Double Gameweek joy
Part 5: Bowen among the best DGW21 picks