This season there seem to be some safe picks from both Manchester City and Chelsea. By this I mean players who are likely to play most weeks.
The likes of Ruben Dias (£6.2m), Joao Cancelo (£6.3m), Antonio Rudiger (£5.8m), Mason Mount (£7.5m), Romelu Lukaku (£11.5m) and Phil Foden (£8.1m), in his current form, seem likely to start in at least nine out of every 10 matches as long as they are fit and available, so looking towards those picks seems wise.
Thankfully, this season there are so many great cheaper options such as Tino Livramento (£4.3m) and Emile Smith Rowe (£5.5m) so, on the odd occasion when those players miss matches, managers will always have a great bench option.
Foden and Mount are both high on my agenda now after their performances last weekend. I've got the flexibility to take a couple of risks on my Wildcard.
With the nature of big squads for the top sides, rotation is inevitable.
With Livramento, Shane Duffy (£4.4m) and Armando Broja (£5.0m) as bench options, managers can invest in Ben Chilwell (£5.8m), Foden and Cancelo knowing that they have backups if they don't play.
Despite the rotation risk of Man City and Chelsea players, owning a few will ensure a good amount of points. Livramento is a great first substitute when there is rotation.
Chilwell and Reece James (£5.5m) are my favourite Chelsea players, with Cancelo and Foden my preferred Man City ones.
After a Gameweek like the one we've just experienced it feels like it would be worth the risk to load up on Chilwell, James and Foden, but not much has changed. They won't start every game and, when they do start, they won't always get a double-figure haul.
Having a strong bench doesn't solve the problem as there is a significant risk of these players seeing minutes as a substitute.
I must admit my Rudiger and Dias picks aren't looking like much fun right at the moment, but they could yet outscore their high-risk, high-rewards counterparts.
Remember, the Gameweek 10 deadline is at 11:00 BST on Saturday 30 October.