The Brighton & Hove Albion centre-back has found the net on five occasions, more than any other defender.
Duffy has also recorded two assists and five clean sheets as the Seagulls prepare to entertain Huddersfield Town.
This is why he is one of four Gameweek 29 Differentials selected by The Scout ahead of the Saturday, 2 March 11:30 GMT deadline.
Brighton's 5.7 per cent owned centre-back has been one of the standout defenders for attacking potential in FPL this season.
Duffy has had 25 shots inside the penalty area, second only to the 30 of Matt Doherty (£5.5m).
He also offers a strong chance of a clean sheet against Huddersfield Town, who have scored only three goals in their last nine matches.
Lanzini has featured as a second-half substitute in each of the Hammers' last two matches and is pushing for his first start of 2018/19.
The 0.1 per cent of managers who own him will look to Lanzini to return to the form of last season, when he scored or assisted 40 per cent of West Ham's goals when selected.
The Liverpool striker is poised to make back-to-back starts for the first time this season, to the delight of the 0.1 per cent of owners who have the Belgian in their squads.
This suggests he can retain his starting role at Everton on Sunday.
Origi's previous appearance in the Merseyside derby was a successful one, scoring the winner in Gameweek 14.
Pedro heads to neighbours Fulham, whose 63 goals conceded are more than any other side, giving confidence to the 3.2 per cent of managers who own him.
The Spaniard has taken advantage of Fulham's frailties this season, scoring and producing 11 points against them in Gameweek 14.
Part 1: GW29 Ones to watch: Maddison ready to kick on
Part 3: GW29 Captains: Aguero and Pogba can topple Salah
Part 4: GW29 Scout Selection: Son backed for derby success
Part 5: GW29 Team news: Rashford ready to start