De Bruyne is one of four Differentials selected by The Scout for Gameweek 24 ahead of the Tuesday 29 January, 18:45 GMT deadline.
The Belgian is free from injury ahead of his trip to Newcastle United.
De Bruyne earned his first 90-minute outing of the season in Gameweek 23, creating four chances in a 3-0 win at Huddersfield Town.
Recalled from a loan at West Bromwich Albion, the young attacking midfielder was handed his first league start in Gameweek 23.
Barnes marked the occasion with an assist in the 4-3 defeat at Wolverhampton Wanderers, and his three attempts on the day were bettered by only one team-mate.
The Arsenal striker was in more than 900,000 FPL squads at his peak in Gameweek 10.
He has lost nearly two thirds of his ownership since then, but has rewarded the 6.4 per cent who have remained loyal with two goals in his last three starts.
Lacazette had a successful outing against Cardiff City earlier this season, scoring and providing an assist to earn 12 points in Gameweek 4.
Babel fired in a team-leading three shots on goal in that match but still only has a 0.1 per cent ownership.
That highlights his attacking threat for the visit of Brighton & Hove Albion, a side with only one clean sheet away from home all season.