The AFC Bournemouth forward is set for a home tie with Huddersfield Town after scoring seven goals and providing seven assists in FPL this season. His total of 14 goal involvements is second only to the 15 of Raheem Sterling (£11.5m).
His effort at Huddersfield last weekend takes the Brighton & Hove Albion centre-back to three goals, as well as two assists, for the season. Duffy faces a home encounter with a Crystal Palace side who have scored just one goal in their last three away trips.
The Everton centre-back has attempted 20 shots inside the penalty area this season, more than any other defender. Keane welcomes Newcastle United in fine form, scoring 31 points in the last six Gameweeks.
The Brazilian has profited from a move up front for Everton. Richarlison's 15-point haul in Gameweek 11 highlights his potential at home to Newcastle.
The Manchester City winger has soared to the top of the FPL points standings on the back of four goals and four assists in the last four Gameweeks. Sterling will be among the captaincy favourites away to Watford.
The Liverpool midfielder has been a big goal threat away from home, with his totals of 26 shots and 10 shots on target each second overall. Salah visits a Burnley team who have conceded 17 goals in the last six Gameweeks.
His 12 shots on target over the last four Gameweeks are at least double any other player. Ominously for Southampton, Kane scored a hat-trick in the corresponding fixture last season.
The AFC Bournemouth forward has fired 35 shots inside the penalty area this season, second among all players. Huddersfield visit Vitality Stadium having conceded 14 goals in six away matches.
The West Ham forward has been involved in 57 per cent of his side’s goals when on the pitch. Arnautovic has five goals and three assists over his 12 starts, and takes on at home a Cardiff side who are without a clean sheet in the last 11 Gameweeks.
WGTA (@WGTA_FPL): An offbeat selection! I'm surprised my new signing Felipe Anderson (£7.1m) hasn't made the cut, and Rose is a name that jumped out. Nonetheless, in what may be a hard week for the template, it could do wonders.
Sam Bonfield (@FPLFamily): I've been keeping Keane on my radar for a while. He is set for a Fantasy haul at some stage as his aerial threat and underlying statistics look excellent. Kane v Southampton as Spurs look to bounce back after the north London derby also looks a good pick. He has excellent fixtures moving forward, too.
Holly Shand (@FFCommunity_): The front three look a great source of goals. I’m nervous to have only Arnautovic, but Kane and Wilson should do well in their home fixtures.
Lee Bonfield (@FPLFamily): The "Pep Roulette" should throw up a surprise or two over Christmas. I'm willing to bet Sterling may get rested, with Riyad Mahrez (£8.5m) coming in. Leroy Sane (£9.4m), though, has played fewer minutes this season and Guardiola gushed over his performance last weekend. I'm backing the German to outperform Sterling in Gameweek 15.