Ahead of the Premier League's Matchweek 13 fixtures, here are the standout facts about each match.
Click on the fixtures to see head-to-head records, past meetings and form guides.
Expect goals in this fixture. Since the start of last season, Leicester City have both scored and conceded in a league-high 32 PL matches.
After Southampton won their last match in London, at Crystal Palace, they have a chance for a first run of two consecutive league victories in the capital since 2014/15, when they beat Palace and QPR.
Juan Mata likes facing Palace at Old Trafford, scoring in two of his three PL home matches for Manchester United against them. The Spaniard is also just one away from 50 goals and 50 assists in the competition.
Manchester City can become only the second non-London club to win six consecutive top-flight fixtures in the capital. The only other team to do so were Portsmouth, between December 1950 and December 1951.
Callum Wilson has scored in all three of his top-flight appearances against Arsenal. The forward can match Charlie Austin's Premier League record of scoring in each of his four matches against the Gunners.
Wolverhampton Wanderers’ Matt Doherty has created 10 PL chances for Raul Jimenez this season. Only Everton’s Gylfi Sigurdsson has created more for one team-mate in the competition, with 12 for Michael Keane.
The home team has scored first in all four PL meetings between these sides but only once have they gone on to win. That was when Burnley triumphed 1-0 in this fixture last season.