Thousands of Fantasy Premier League managers' worst fears were confirmed on Friday when Kevin De Bruyne (£9.9m) was ruled out for up to three months.
The Belgian was the second-most popular midfielder in Gameweek 1 and has so far been sold by over 573,000 owners ahead of Saturday’s 11:30 BST deadline.
De Bruyne's injury could raise the chances of more minutes for his Manchester City team-mates, starting against Huddersfield Town on Sunday.
Silva lining
Bernardo Silva (£7.6m) and Ilkay Gundogan (£5.5m) both started last weekend’s win at Arsenal in the advanced central-midfield roles of City's 4-1-2-3 formation.
Silva's versatility could make him the best De Bruyne replacement.
He scored the second goal in the 2-0 victory at Emirates Stadium and could continue in the middle or move out wide in Pep Guardiola’s front three.
David Silva (£8.5m) may be set to return against the Terriers and is owned by only four per cent of managers.
“Last week he was not fit – he had a problem in his leg – but he trained well in last two or three days," Guardiola told City's official website of the Spaniard.
Richarlison passed fit
Everton’s popular winger Richarlison (£6.6m) is also available for Gameweek 2 after a calf problem.
The Brazilian scored two goals on his first appearance away to Wolverhampton Wanderers before being replaced due to that injury.
Richarlison is the third-most owned midfielder in the game, sitting in 22 per cent of squads.
He has claimed more than 207,000 transfers in ahead of a home debut against Southampton.
