Here is how they did in their first match in the PL and how they have fared since.
First match: George Graham's team squandered a two-goal lead to go down 4-2 at home to Norwich City.
Since: Under the reign of Arsene Wenger, Arsenal have gone on to become one of the most successful clubs, with three Premier League titles.
Highest finish: Champions (1997/98, 2001/02, 2003/04)
Lowest finish: 12th (1994/95)
First match: A late Nick Henry goal meant Oldham Athletic denied Chelsea a winning start to the Premier League with a 1-1 draw at Stamford Bridge.
Since: The arrival of Roman Abramovich in 2003 ushered in a successful era that has featured five PL titles, three won under Jose Mourinho.
Highest finish: Champions (2004/05, 2005/06, 2009/10, 20013/14, 2016/17)
Lowest finish: 14th (1993/94)
First match: Barry Horne cancelled out Nigel Pearson's early strike at Goodison Park as Everton opened with a draw with Sheffield Wednesday.
Since: After flirting with relegation early on in the competition, Everton have largely secured top-half finishes with their best years coming under David Moyes.
Highest finish: 4th (2004/05)
Lowest finish: 17th (1993/94, 1997/98, 2003/04)
First match: Liverpool's match at Nottingham Forest was the first in the Premier League to be broadcast live on television, with Teddy Sheringham scoring the only goal.
Since: Three times runners-up, the closest Liverpool have come to an elusive first PL title was under Brendan Rodgers in 2013/14.
Highest finish: 2nd (2001/02, 2008/09, 2013/14)
Lowest finish: 8th (1993/94, 2011/12, 2015/16)
First match: United conceded the competition's first goal, to Brian Deane, and lost 2-1 to Sheffield United on the opening day.
Since: They recovered to claim the title that season and 12 more since, all under Sir Alex Ferguson, to become the competition's most successful team.
Highest finish: Champions (13 times)
Lowest finish: 7th (2013/14)
First match: Doug Livermore's Spurs team kicked off the inaugural Premier League with a goalless draw at Southampton.
Since: Spurs' best seasons have been in recent years, coming second last term in their ninth successive top-six finish.
Highest finish: 2nd (2016/17)
Lowest finish: 15th (1993/94)