Romelu Lukaku (£11.7m) has been the most popular selection for the armband in each of the first four Gameweeks.
But Kane now has momentum and a promising fixture in his favour.
He ended his recent drought with a double at Everton last weekend.
With two goals over the international break and another brace in the UEFA Champions League win over Borussia Dortmund, Kane has six goals in his last four matches for club and country.
Spurs face Swansea City in Gameweek 5.
The Swans arrive at Wembley Stadium having conceded more shots than any other side (78).
Kane scored twice in the corresponding fixture last season in a 5-0 win.
He also ranks top for shots (28) and shots inside the box (21) after the first four Gameweeks.
A pair of Spurs midfielders could also pick up big points against the Swans.
Christian Eriksen (£9.7m) fired a brace in the home fixture in 2016/17.
He is the most-bought attacking player for the Gameweek, attracting 190,000+ new owners.
Dele Alli (£9.5m) missed Wednesday’s European match through suspension and should be fully refreshed for Saturday’s fixture.
He has surpassed Eriksen (seven to four) for shots on goal and matched him for chances created (six) in home matches.
Lukaku will remain a hugely popular captaincy option.
He welcomes former club Everton to Old Trafford in fine form.
A midweek strike in the UEFA Champions League win over Basel took his tally to six goals in as many matches across all competitions.
Owned by 57% of FPL managers, Lukaku has scored 18 goals in his last 20 home appearances in the Premier League.
Both players have recorded two sets of double-figure returns in the first four Gameweeks.
No player in the Premier League has more shots on target than Salah's nine.
Jesus has produced 21 points in the last two Gameweeks and supplied a goal and assist at Vicarage Road in 2016/17.
Aguero grabbed two goals and an assist that day; it was one of five occasions he scored twice away from home last season.
Alvaro Morata (£10.2m) is yet another in-form striker vying for the armband.
The FPL GW5 deadline is Friday 15 September, 19:00 BST