Should he find the net at the Etihad Stadium, Aguero would become only the fourth player to score in six consecutive home PL matches against the same opponent.
The Manchester City forward could go level with Alan Shearer (six for Blackburn Rovers and Newcastle United v Everton), Thierry Henry (for Arsenal v Aston Villa) and Jimmy Floyd Hasselbaink (for Leeds United, Chelsea and Middlesbrough v West Ham United).
Aguero’s run against Liverpool began in his debut season in 2011/12, when he opened the scoring in a 3-0 win.
The next season he found the net with a spectacular finish from a tight angle to earn City a 2-2 draw, before missing the 2013/14 meeting through injury.
He struck again in 2014/15 as City won 3-1, but his goal a year later was merely a consolation in a 4-1 defeat.
Last season, the Argentinian made it five home matches in succession when his 69th-minute close-range finish cancelled out a James Milner penalty.
Aguero will now hope to make it six in a row, while he will also be keen to end up on the winning side at home against Liverpool for only the third time.