Liverpool will kick off the new-look 2017/18 Under-18 Premier League with a trip to Derby County on Friday 11 August, in what will be Steven Gerrard's first match as coach of the Reds' U18 team.
The 1pm kick-off will be followed by a full programme of fixtures on Saturday, with defending champions Chelsea starting with a visit to Aston Villa.
Scott Parker begins his competitive career as Tottenham Hotspur's U18 coach with a home tie against Norwich City. Newcastle United v Manchester City is another standout match on the opening weekend.
The competition will remain as two 12-team regional divisions, the North Group and the South Group, but the format following the regular League format has changed.
The North Group winners and South Group winners will contest a national final for the U18 Premier League title. It will be a one-off tie at a main stadium.
Derby County v Liverpool, 1pm, Derby County Training Ground
Blackburn Rovers v Middlesbrough, 12pm, Blackburn Rovers Training Ground
Newcastle United v Manchester City, 11am, Newcastle United Academy
Everton v Stoke City, 11am, Finch Farm Training Complex
Wolverhampton Wanderers v West Bromwich Albion, 11am, Sir Jack Hayward Training Ground
Aston Villa v Chelsea, 11am, Aston Villa Training Ground
Brighton & Hove Albion v West Ham United, 11am, American Express Elite Football Performance Centre
Fulham v Arsenal, 11am, Fulham FC Training Ground
Reading v Swansea City, 1pm, Reading FC Training Ground
Southampton v Leicester City, 12pm, Staplewood Training Ground
Tottenham Hotspur v Norwich City, 12pm, Tottenham Hotspur Training Ground