Spurs closed the gap to leaders Chelsea to four points with wins against Burnley, Swansea City, Watford, AFC Bournemouth and Crystal Palace before a 2-0 victory in the final north London derby at White Hart Lane, ensuring they finish above Arsenal for the first time since 1994/95.
During the month the 45-year-old's side scored 16 goals, conceding just once.
"For me it's an award, a trophy that deserves to be shared with everyone at the club."— Tottenham Hotspur (@SpursOfficial) May 12, 2017
A humble Mauricio on his manager of the month award. pic.twitter.com/W5gc8kk48U
"I feel proud because it is a collective reward," Pochettino said after winning the award for the fourth time in his Premier League career.
"It means a lot for everyone here. It's a trophy that deserves to be shared with all at the club."
Pochettino won thanks to a combination of votes from a panel of experts and the public. He beat fellow nominees Marco Silva, of Hull City, Manchester United manager Jose Mourinho, Leicester City's Craig Shakespeare and Antonio Conte, of Chelsea.