Assisting two goals, the Belgian contributed four key passes in total, while also winning five tackles to total 45 in the Bonus Points System (BPS).
Vincent Kompany (£5.9m) opened the scoring and was awarded two bonus points.
The centre-back also completed an impressive 90% of his 70 attempted passes and totalled five clearances, blocks and interceptions (CBI) to tally 40 in the BPS.
Fellow City defender Gael Clichy (£5.2m) picked up the final bonus point with a BPS score of 32 after winning two tackles, contributing seven recoveries and completing 90% of his 78 attempted passes.
Sergio Aguero (£12.8m), who scored City’s third, missed out on bonus points having been tackled eight times and missing the target with three shots.
De Bruyne’s dominance was also reflected in the ICT Index, where he led with a score of 13.7.
He tallied 58 for Creativity, the highest in the match, completing three of 12 attempted crosses and creating four chances.
Aguero has scored in six of his last seven Gameweeks and yet owners continue to dump him.
He was sold by nearly 41,000 ahead of Gameweek 33 as managers scrambled for Harry Kane (£11.5m).
The Argentinian's failure to deliver double-figure scores has also harmed his prospects. On only four occasions this season has he scored at least 10 points, with his last such haul back in Gameweek 13.
Five of Man City’s final six matches, including their two fixtures in Gameweek 37, score two in the Fixture Difficulty Rankings (FDR).
However, that schedule may do little to boost Aguero's FPL stock should Gabriel Jesus (£8.7m) challenge for his starting role over the run-in.
The Brazilian is closing on a return after a foot injury at AFC Bournemouth in Gameweek 25.
Leroy Sane (£7.6m) scored City’s second on Saturday, making it four goals and two assists over his last 11 Gameweeks.
The German's appeal is heightened by the fact he has started each of those 11 encounters.
By contrast, Raheem Sterling (£7.6m) was moved to the bench on Sunday to underline the uncertainty over his pitch-time. The winger has started in just three of the last six Gameweeks.