The Aston Villa left-back has made a major impact at both ends of the pitch at Villa Park recently, combining two assists with four clean sheets in his previous six.
He totalled 31 points across that run, producing returns in all six matches.
Moreno is joined by his team-mate Ollie Watkins (£7.7m) in a side that lines up in a 3-4-3 formation, with Erling Haaland (£12.3m) handed the armband and Mohamed Salah (£13.0m) named vice-captain.
Jose Sa (WOL) £5.0m
The Wolverhampton Wanderers goalkeeper hosts Crystal Palace on the back of three clean sheets in four at Molineux. Indeed, Sa is the top-scoring goalkeeper in home matches this season, amassing 89 points.
Trent Alexander-Arnold (LIV) £7.5m
Liverpool’s right-back has been revived in Fantasy thanks to a recent move into central midfield. Alexander-Arnold has supplied four of his eight assists this season in the Reds' last three matches ahead of their trip to West Ham United.
Kieran Trippier (NEW) £6.2m
Newcastle United’s right-back has created 18 chances across the previous four Gameweeks, joint-top among all players in Fantasy. Trippier faces an Everton side who have scored only one goal in their last three outings.
Alex Moreno (AVL) £4.5m
The Villa full-back produced a season-high score of 10 points in his last home appearance.
Mohamed Salah (LIV) £13.0m
Liverpool’s talisman has scored in three successive Gameweeks for the first time in 2022/23 ahead of facing West Ham. Salah averages 10.2 points per match in away meetings with the Hammers, highlighting his credentials as a major captaincy option.
Marcus Rashford (MUN) £7.1m
The Manchester United star faces a Tottenham Hotspur side who have conceded nine goals in their last two matches. Rashford has amassed 112 points since the season resumed, joint-top among all players in Fantasy.
Gabriel Martinelli (ARS) £6.9m
The winger's form on the road suggests he will be Arsenal’s key attacking threat for their trip to title rivals Manchester City. Martinelli has 42 points in his last five away fixtures, thanks to four goals, two assists and no blanks.
Kaoru Mitoma (BHA) £5.6m
Mitoma has averaged 6.1 points per start since his full Brighton & Hove Albion debut in Gameweek 14. He visits a Nottingham Forest side who have lost four successive fixtures, conceding at least twice in each of those occasions.
Erling Haaland (MCI) £12.3m
The Man City striker averages 10.1 points per home start in his debut Fantasy campaign. Haaland can deliver yet another huge haul against an Arsenal side who have conceded at least twice in each of their previous three.
Ollie Watkins (AVL) £7.7m
The Villa forward has 55 points in the last six Gameweeks, scoring six goals and supplying two assists. Watkins recorded his season-high haul of 16 points in his last home match in a 3-0 win over Newcastle.
Ivan Toney (BRE) £7.6m
Brentford’s forward is the sixth top-scoring player in away matches this term, earning 86 points thanks to nine goals and two assists. Toney makes a short trip to Chelsea, looking to exploit a side who have conceded 23 shots in the box in their two matches under Frank Lampard, the fourth-worst total in the league.