The Newcastle United right-back is the second top-scoring defender in Fantasy, amassing 55 points from the first 11 Gameweeks.
Trippier has been particularly reliable at St James' Park this season, producing returns in each of his five outings.
He has averaged 6.6 points per home match, thanks to one goal, two assists and two clean sheets.
Trippier is included in a best XI that lines up in a 3-5-2 formation, with Mohamed Salah (£12.7m) handed the armband and Wilfried Zaha (£7.5m) named as vice-captain.
Vicente Guaita (CRY) £4.5m
The Crystal Palace stopper has produced two clean sheets and 22 points in his last four outings. Guaita can get more returns at home to a Wolverhampton Wanderers side who have failed to score in their last four on the road.
Kieran Trippier (NEW) £5.7m
He is the most-owned defender in Fantasy, found in more than 57 per cent of squads.
Lewis Dunk (BHA) £4.6m
The Brighton & Hove Albion centre-back's aerial threat can exploit Nottingham Forest's weaknesses at defending set-pieces. Dunk's visitors have one away goal this season, also lifting his prospects of a clean sheet.
Timothy Castagne (LEI) £4.4m
Leicester City's full-back welcomes Leeds United in his most consistent form of the campaign. Castagne has 23 points in his last four appearances, combining an assist with three clean sheets and three bonus points.
Mohamed Salah (LIV) £12.7m
Liverpool's Egyptian is the most-bought player in the Gameweek, earning over 320,000 new owners on the back of four goals in his last two matches in all competitions. Salah has a prolific record at home to West Ham United, scoring in four of their five meetings at Anfield.
Mason Mount (CHE) £7.7m
Wilfried Zaha (CRY) £7.5m
Palace's talisman has blanked only once in his last four home outings, earning 26 points thanks to three goals and an assist. Zaha faces a Wolves side who have conceded five goals in their last two away matches.
Harvey Barnes (LEI) £6.9m
An ownership under 2.0 per cent makes the Leicester winger a big differential at home to Leeds. Barnes has produced 10 shots in the box in the last four Gameweeks, a total bettered by only two other midfielders in Fantasy.
Leandro Trossard (BHA) £6.9m
Brighton's Belgian has delivered 12 and 20-point returns in his last four outings. Trossard's potential for huge hauls makes him a strong captaincy choice against a Forest side who have conceded 11 goals in their last three away matches.
Harry Kane (TOT) £11.4m
Tottenham Hotspur's forward visits Manchester United in an outstanding run of form in Fantasy. Kane has produced returns in nine successive appearances, averaging 7.8 points per match from Gameweek 2 onwards.
Aleksandar Mitrovic (FUL) £6.7m
Fulham’s fit-again forward returned to action with a goal against AFC Bournemouth last weekend. Mitrovic’s home form will be crucial against Aston Villa, the Serbian scoring five of his seven goals this season at Craven Cottage.
GW12 deadline: 18:00 BST, Tue 18 Oct
Also in this series
Part 1: GW12 Ones to watch: Salah surges back into the spotlight
Part 2: GW12 Differentials: Guehi provides value solution
Part 4: FPL experts: Trossard heads top Maddison replacements
Part 5: The FPL Pod: Best options for the Man City and Arsenal blank
Part 6: FPL experts: Who to captain in Gameweek 12
Part 7: GW12 Captains: Zaha can extend home run