Adrian Clarke looks at key tactical points in Matchweek 15.
It remains to be seen if he will deploy a familiar back three or gamble on starting with a 4-2-3-1 formation, which allows him to start an additional attacker.
Without Raul Jimenez, Wolves lack a focal point and pose less of a goal threat.
So the inclusion of an extra forward may compensate for that, if Nuno decides to take a front-footed approach.
Wolves' record with an experimental back four between Matchweeks 9 and 12 was one win, a draw and two defeats.
But while results were mixed they still impressed as an attacking unit.
In these matches Wolves had more efforts on goal from close range and it was a tactical move the players appeared to enjoy.
Failure to keep a clean sheet in those four outings will have been a concern, but they did not suffer too much defensively from the formation switch.
|Per 90||Back three||Back four|
|Touches in opp. box||17.3||24.5|
|Shots in box||6.0||10.0|
Nuno went with his tried and trusted three-man defence in their last home fixture as they beat Chelsea 2-1.
But he did change to a 4-2-3-1 for the final 30 minutes of their 2-1 defeat at Burnley.
During that period of the match, Wolves created four of their six best chances and scored a late penalty.
Nelson Semedo has impressed at right wing-back, but in recent fixtures Wolves’ opponents have exposed gaps down his side of the pitch.
Jose Mourinho’s team could look to profit from this vulnerability.
Against Villa, Semedo brought down John McGinn to give away what proved to be a match-winning penalty.
Semedo likes pushing forward but with no fixed right-sided midfielder ahead of him, he has found himself isolated and short of cover.
A greater reliance on Neto and Podence to supply goals means these two players stay upfield for longer periods.
Leander Dendocker will come across from central midfield to support Semedo, but it is not ideal for him to leave his position.
Therefore it would not be a surprise if Adama Traore was named in the starting XI on the right ahead in front of Semedo.
The Portuguese defender will hope he is afforded more protection, otherwise he and Wolves could struggle to deal with Spurs.