Anfield has been a fortress in recent years for champions Liverpool and if they avoid defeat against West Ham United on Saturday they will equal a club record.
For more on this and all the must-know stats for Matchweek 7, read on. To check out the head-to-head records, click on the fixtures.
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Wilfried Zaha needs one goal or assist to match his total of seven goal involvements from last season.
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Sheffield United are aiming to avoid starting a season with no wins in seven matches for the first time since 1991.
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Edouard Mendy can become the first Chelsea goalkeeper since Petr Cech in 2004 to start with three consecutive Premier League clean sheets.
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If they avoid defeat, Liverpool will equal their longest-ever unbeaten home run of 63 matches at Anfield.
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A win would give Ralph Hasenhuttl the joint-most away Premier League wins as a Southampton manager, level with Ronald Koeman's 14. Hasenhuttl has the best points-per-match ratio in away matches of any Saints boss, with 1.42.
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Newcastle United are aiming to avoid going eight home matches without a clean sheet for the first time since 2014.
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Manchester United are unbeaten in their last 13 home Premier League matches v Arsenal since 2006 (W8 D5).
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If Harry Kane scores twice in his 217th match he will be the joint-second quickest player to reach 150 Premier League goals, level with Sergio Aguero and only behind Alan Shearer's 212 matches.
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Fulham hope to avoid being the 12th side in history to lose their first four home matches of a top-flight campaign.
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Leicester City are looking to win five of their first seven matches of a top-flight season for the first time.