The Aston Villa playmaker sits joint-third among midfielders on 35 points, despite only playing three matches.
Grealish has scored three goals and also supplied three assists, producing a season-high haul of 24 points against Liverpool in Gameweek 4.
He now faces a Leicester defence that has conceded at least twice in each of its last four matches in all competitions.
Grealish takes his place in a Scout Selection that lines up in a 3-5-2 formation, with Mohamed Salah (£12.2m) handed the armband and Son Heung-min (£9.1m) given the vice-captaincy.
The Crystal Palace goalkeeper welcomes Brighton & Hove Albion on the back of some fine home form. Guaita has produced 12 points over his two matches at Selhurst Park this term, including a 10-point haul in Gameweek 1.
Sheffield United’s wing-back can bring in points at both ends of the pitch. Baldock supplied his first assist of the season in Gameweek 4 and hosts a Fulham side who have failed to score in their last three matches in all competitions.
The right-back looks set to return to Chelsea's starting XI at home against Southampton, with doubts over the fitness of Ben Chilwell (£5.6m). He has created eight chances this season, more than any team-mate.
Salah can capitalise against an Everton side that have conceded twice in both of their home matches in 2020/21. His 19 shots, 15 shots inside the box and 14 chances created are all league-leading totals.
Boasting a flawless away record since joining Manchester United last January, Fernandes has produced attacking returns in all eight of his matches on the road ahead of Saturday's visit to Newcastle United.
FPL's top-scoring player has earned over one million new owners ahead of Tottenham Hotspur's home fixture against West Ham United. Son has four goals and four assists from his last six appearances against the Hammers.
The third most-bought midfielder ahead of Saturday's 11:00 BST deadline, Grealish has over 450,000 new owners.
Manchester City's wide man offers a relatively budget-friendly route into Pep Guardiola's attack against Arsenal. Mahrez produced 12 points in his last home appearance, scoring once and providing an assist against Leicester City.
Four goals and an assist in the opening four Gameweeks highlight his impact since arriving at Newcastle United this summer. Wilson faces a Man Utd defence who have conceded 11 goals in their three matches this season.