Calvert-Lewin’s new owners will be encouraged by his visitors’ poor defensive display against Leicester City.
The Baggies conceded four big chances and seven shots on target in the 3-0 defeat, both more than any other side in Gameweek 1.
Calvert-Lewin is named in a 4-4-2 formation, with Pierre-Emerick Aubameyang (£12.0m) handed the armband and Marcus Rashford (£9.5m) named vice-captain.
Aston Villa’s new No 1 can make an immediate impact by claiming a clean sheet against Sheffield United. Dean Smith’s side recorded seven shutouts at home last season, the same number as Liverpool and Manchester United.
The Everton left-back was far more reliable at home last term, producing seven of his eight assists at Goodison Park. Digne looks poised for points at both ends of the pitch against West Brom.
A visit from Crystal Palace gives the Man Utd defender the chance to continue his fine form from the end of 2019/20. Three of Wan-Bissaka’s four assists and nine of his 12 clean sheets came in his final 13 starts.
Newcastle United's new left-back kept a clean sheet and earned one bonus point on his debut at West Ham United. Lewis' three key passes in Gameweek 1 suggest his raids forward will trouble Brighton & Hove Albion at St James' Park.
The Arsenal man has scored four goals across his last three appearances. At home against West Ham, Aubameyang seems very likely to remain as the most-selected captain in FPL for Gameweek 2.
His nine shots and eight shots in the box were both more than any other player in Gameweek 1. Salah looks back to his very best as Liverpool make their way to Chelsea.
His average of 8.4 points per match was more than any other player in FPL last season. Fernandes is the most-bought player for Gameweek 2, with more than 385,000 managers rushing to snap up the Portuguese.
At home last season, his 12 goals and 53 shots were both more than any other Man Utd player. His low ownership of 6.0 per cent means Rashford can be a huge differential for the armband in Gameweek 2.
Newcastle's frontman got off the mark on his debut at West Ham, earning eight FPL points. Wilson has a strong record against his visitors, Brighton, with three goals and two assists in five matches while at AFC Bournemouth.
The Toffees striker was transformed after Carlo Ancelotti was appointed manager in Gameweek 19 last season. Calvert-Lewin produced 60 shots from that point onwards, second only to the 76 of Salah among all players in FPL.
Don't get caught out. GW2 deadline: 11:00 BST on 19 September.