The Tottenham Hotspur forward has a prolific record against the Toffees, scoring twice in four of their last five meetings.
Kane can take advantage of an Everton side who struggled on their travels last term.
They managed only three away clean sheets, conceding at least twice in five of their 10 road trips under Carlo Ancelotti.
Son Heung-min (£9.0m) provides an in-form route into the Spurs attack.
The South Korean has been involved in six of his side's nine goals over pre-season, scoring four and supplying two assists.
The most-owned midfielder or forward in FPL, he sits in 47.9 per cent of squads for his visit to Brighton & Hove Albion.
Werner scored 28 goals and supplied eight assists in the 2019/20 Bundesliga.
The Leicester City striker has scored in all four of his visits to The Hawthorns.
When selected, he was involved in 61 per cent of Southampton's goals on the road last term.
Saints' frontman scored 12 away goals in 2019/20, second only to the 14 of Raheem Sterling (£11.5m) in FPL.
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