There will be more than local pride at stake for Sergio Aguero when he heads across Manchester to Old Trafford on Sunday.
With a goal against Ole Gunnar Solskjaer's side, he would equal the highest total for Premier League goals scored by a visiting player at the Theatre of Dreams, currently held by a Liverpool great.
And with a second strike, he would match the record for goals scored in Manchester derbies across all competitions.
For more on this and all the must-know facts for Matchweek 29, read below. To see the head-to-head records and key data for the matches, click on the fixtures.
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Liverpool can become only the second club in top-flight history to beat the same team by at least three goals in six successive meetings, after Manchester City did so against Wolverhampton Wanderers between 1902 and 1905.
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Arsenal have scored at least three goals in 12 of their last 16 Premier League matches against West Ham United, including their last three against them at Emirates Stadium.
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Watford are unbeaten in five matches against Crystal Palace in all competitions, winning three and drawing two, since a 2-1 defeat in December 2017 at Selhurst Park.
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Norwich City have given 7,026 minutes to players aged 21 or under this season, more than any other Premier League side.
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Newcastle United's head coach Steve Bruce is aiming for his first league win at Southampton at the seventh attempt. In his previous six matches at St Mary’s Stadium, he has drawn two and lost four.
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Wolves can win a third consecutive Premier League match for the first time since May 2019. In their last two victories they have scored six goals, as many as in their previous seven Premier League fixtures combined.
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This is the 100th league meeting between Burnley and Tottenham Hotspur. Spurs have won 39 of those matches compared to Burnley’s 36.
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Richarlison has been directly involved in three goals in five Premier League matches against Chelsea, scoring two and creating another. He can now become the first Brazilian to find the net in three consecutive Premier League appearances against the Blues.
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Sergio Aguero has scored nine times in Manchester derbies in all competitions. Only Wayne Rooney (11), Joe Hayes (10) and Francis Lee (10) have netted more. Aguero has struck four times in Premier League fixtures at Old Trafford, with Steven Gerrard the only visiting player to score there more often in the competition, with five goals.
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Kelechi Iheanacho has scored in all three of Leicester City's matches against Aston Villa this season. Romelu Lukaku was the last Premier League player to net against the same side in four different matches in a single campaign, when he faced West Ham in 2014/15.