The Egyptian's 13-point haul was his first double-figure Fantasy Premier League return since Gameweek 3.
Many managers have swapped the 21.3 per-cent owned Salah for Mane in recent weeks, but it was not a happy Saturday for the latter.
Mane’s 42.8 per cent owners were left frustrated after he was among seven players rotated by Jurgen Klopp at Vitality Stadium.
Naby Keita (£5.8m) was one who came in and he equalled Salah’s goal and assist to record 14 points.
Trent Alexander-Arnold (£7.3m) came off the bench in the first half after an injury to Dejan Lovren (£5.3m), but he played only 50 minutes and missed out on clean-sheet points with Andrew Robertson (£7.1m) outscoring him by six points to one.
They scored a goal apiece in a 2-1 derby win at Manchester City.
Dominic Calvert-Lewin (£5.7m) was another forward to catch the eye on Saturday.
He scored twice and provided an assist in a 5-0 home win over Burnley.
Kane’s 16 points are his highest of the season and his first double-digit return since Gameweek 1.
Son combined an outstanding individual goal with an assist against the Clarets, while Alli set up two goals.
They have 37 and 38 points respectively in their four matches since the Portuguese was appointed head coach.
Jan Vertonghen (£5.2m) impressed in defence for Spurs, with an assist and clean sheet earning him 11 points.
Crystal Palace claimed a third successive clean sheet thanks to a goalless draw at bottom-club Watford.
Goalkeeper Vicente Guaita (£5.0m) has been their standout player, producing 26 points in that run of matches.
Their run of opponents points to more clean sheets for Roy Hodgson’s men.
According to the Fixture Difficulty Ratings (FDR), four of Palace’s next five matches score just two.