Sergio Aguero limped off in the second half after picking up an injury that has ruled him out of a crucial run of fixtures.
It is a blow as City head into what Guardiola describes as the "toughest period" for his team.
But could there be a silver lining for City?
While Aguero lies third in the race for the Golden Boot, only one of his nine Premier League goals has been scored since the end of September.
And in Gabriel Jesus they have a replacement striker whose win percentage is higher than Aguero's in matches he starts.