As a result, he is the most-sold player ahead of Saturday's 11:30 BST deadline, moved on by 261,000+ managers and counting.
However, De Bruyne's absence is expected to be a short-term one.
"After international break he will be ready," the manager told Man City's official website. "It's not a big problem."
De Bruyne has enjoyed an outstanding start to 2019/20, scoring two goals and supplying nine FPL assists in the first seven Gameweeks.
Indeed, he is the top-scoring player in the game, with 63 points.
And De Bruyne's upcoming schedule suggests his remaining 39.3 per cent owners should think twice before selling.
According to the Fixture Difficulty Ratings (FDR), all three of his opponents over Gameweeks 9-11 score only two.
De Bruyne's potential for huge points hauls means owners may be best keeping him and instead look to players on their benches for Gameweek 8.