Sterling scored against both teams earlier in the season and earns the armband for Gameweek 25, with Sane handed the vice-captaincy.
The goalkeeper offers a secure option for City’s two matches. Ederson has produced 97 points this season, at least 10 more than any defensive team-mate.
Crystal Palace’s left-back could be set for his fourth double-digit haul of the season at home to Fulham. His six shots and seven key passes in the last four Gameweeks both rank among the top four for defenders.
The Brighton & Hove Albion centre-back has had six shots inside the box in the last four Gameweeks, more than any other defender. Duffy could add to his four goals and two assists this season as Watford travel to the Amex.
A trip to West Ham United can help Salah to his seventh double-figure haul in 10 attempts. He scored two goals in this fixture in 2017/18.
His average of 6.9 points per match (ppm) is second only to the 7.5ppm of Salah among regular FPL starters. Owned by just 11.4 per cent, Sterling could be a huge differential for his two fixtures.
The German has produced five double-figure hauls this season, joint-top with Sterling for City. Sane heads into the Double Gameweek in fine form, with 32 points over the last four Gameweeks.
The Everton playmaker’s record at Goodison Park boosts his chances for the visits of Wolverhampton Wanderers and Man City. At home, Sigurdsson’s 36 shots on goal rank second among FPL midfielders.
The Spurs forward marked his first home start of the season with a 12-point haul against Watford. Llorente faces a Newcastle United defence with one clean sheet in their last six on the road.
The Mexican is among the top five forwards for FPL points, level with Aguero on 113. Jimenez netted against Everton, back in Gameweek 1.
What the experts say
Ben McNair (@drbenmcnair): I'm not so keen on Duffy and David Luiz; they each conceded four goals in midweek. Matt Doherty (£5.2m) should be in there against an Everton side who may be without an experienced left-back.
Mark McGettigan (@FPLGeneral): I like the Sigurdsson pick. He could be the Double Gameweek hero. Sane, Sterling and Ederson are the top three Man City players for their two matches. I am surprised to see Duffy after Brighton conceded four in midweek. I always fancy Watford to score.
Holly Shand (@FFCommunity_): Sigurdsson is interesting. He'd be my pick from Everton as he’s on set-pieces and penalties. With clean sheets hard to come by, Van Aanholt appeals as a potential Marcos Alonso (£6.5m) replacement. He has great fixtures and plenty of attacking threat.
Lee Bonfield (@FPLFamily): In a week where Double Gameweek players will clearly dominate, I’m pleased to see some Spurs representation, although I would have moved for Son Heung-min (£8.6m). Van Aanholt is another top pick. He should cause havoc down that side against Fulham.
Sam Bonfield (@FPLFamily): Another appearance for Llorente! But, Son should be the Spurs asset to own. I agree Sigurdsson is the Everton player to have for the Double Gameweek.
Essential GW25 reading
Part 1: GW25 Ones to watch: Sane can offer double delight
Part 2: GW25 Captains: Double Gameweek players dominate
Part 3: FPL player prices: Almiron will raise Newcastle threat
Part 4: GW25 Differentials: Wood can extend Burnley run
Part 5: GW25 Team news: Digne owners turn to Keane