Manchester City are looking to bounce back from their surprise defeat by Newcastle United in midweek with a fifth win in six matches, while Arsenal can record a fourth victory in five.
Benjamin Mendy and Ederson (both knee) could be in contention for Manchester City but Vincent Kompany is out.
Arsenal will assess the fitness of Laurent Koscielny (jaw), Ainsley Maitland-Niles (knee) and Henrikh Mkhitaryan (foot).
Midfielder Denis Suarez could make his debut, after joining on loan from Barcelona on deadline day, but Sokratis, Danny Welbeck (both ankle) and Rob Holding (knee) are out.
Man City can make it four wins in a row in the top flight against Arsenal for the first time since April 1937.
Arsenal have lost 11 of their last 19 away Premier League matches, keeping just one clean sheet, a 1-0 win at Huddersfield Town in May 2018.
City have lost three of their last seven PL matches when scoring first, after having lost only three of their previous 96 when doing so.
Sergio Aguero has scored in seven of his last 11 matches against Arsenal in all competitions, but he has not found the net in his last two.
Referee: Martin Atkinson
Assistants: Stephen Child, Lee Betts
Fourth official: Craig Pawson