Spurs are targeting their seventh victory from eight Premier League matches, while Manchester United are aiming for their fifth straight top-flight win.
Midfielders Eric Dier (appendicitis) and Victor Wanyama (knee) remain unavailable for Spurs, while Lucas Moura (knee) faces a late fitness test.
Manchester United welcome back Paul Pogba (leg) for the trip to Wembley Stadium, but Marcos Rojo and Chris Smalling (foot) are out.
Alexis Sanchez is doubtful after suffering a recurrence of his hamstring injury and Eric Bailly is suspended.
Spurs are aiming to be the first team since Everton in 1987 to win four consecutive top-flight home matches against Man Utd.
Harry Kane and Lucas Moura could become the third and fourth players to score both home and away for Spurs against United in the same PL campaign.
Man Utd are seeking to improve their PL away record in London, having won just four of their last 17 matches in the capital.
Marcus Rashford is looking to score in a third consecutive PL match for the first time.
Referee: Mike Dean
Assistants: Darren Cann, Dan Robathan
Fourth official: Andre Marriner