Brighton are aiming to extend a three-match unbeaten run in the Premier League, while leaders Liverpool are seeking to respond after back-to-back defeats in all competitions.
Bernardo (hamstring) and Jose Izquierdo (knee) will miss out for Brighton against the Premier League leaders, while Mat Ryan and Alireza Jahanbakhsh are away on Asian Cup duty.
Liverpool's Dejan Lovren (hamstring), Adam Lallana (muscular), Joe Gomez (ankle) and Alex Oxlade-Chamberlain (knee) are out.
Joel Matip (collar bone) is back in training and will face a late fitness test along with Jordan Henderson (knock).
Liverpool are unbeaten at Brighton in the top flight, while their last five trips there in the league have featured 25 goals, 16 of them going to the Reds.
Chris Hughton is looking for his first PL point against Liverpool as a manager at the seventh attempt.
The Reds have won their last eight PL matches kicking off at 3pm on a Saturday, with seven of those victories coming by a margin of at least three goals.
Mohamed Salah has scored twice and assisted two more goals in his three PL appearances against Brighton.
Referee: Kevin Friend
Assistants: Simon Long, Richard West
Fourth official: Roger East