Newcastle United will be eyeing just a second win in eight PL matches but face an in-form Manchester United, who have won their last three, scoring 12 goals in the process.
Newcastle will be without Florian Lejeune and Federico Fernandez (hip), while Ki Sung-yueng is on international duty at the Asia Cup.
Ciaran Clark faces a late fitness test on his ankle injury.
Man Utd caretaker manager Ole Gunnar Solskjaer is without centre-backs Eric Bailly (suspension), Chris Smalling and Marcos Rojo (both injury).
Alexis Sanchez, returning from injury to earn a place on the bench last time out, is in contention to start.
Paul Pogba can become only the second Man Utd player to score at least two goals in three consecutive Premier League appearances after Cristiano Ronaldo in December 2006.
After beating Man Utd 1-0 at St James' Park last season, Newcastle can claim back-to-back home league victories against the Red Devils for the first time since 1987.
Newcastle manager Rafael Benitez has won each of his last four home matches with English clubs against Man Utd in all competitions, twice with Liverpool, once with Chelsea and also with Newcastle last season.
Ole Gunnar Solskjaer can become only the second manager in Man Utd's history to win his first four league matches in charge, after Matt Busby in 1946.
Referee: Andre Marriner
Assistants: Scott Ledger, Simon Long
Fourth official: Stuart Attwell