Brighton & Hove Albion are on a run of three straight PL defeats while Arsenal go into the contest having lost only one of their last 16 in the Premier League.
Joe Izquierdo (knee) and Alireza Jahanbakhsh (hamstring) will miss Wednesday’s match, while Lewis Dunk will serve his one-match suspension.
Albion welcome back Shane Duffy from his three-match ban with the Irishman expected to play alongside Leon Balogun at centre-back.
Arsenal's Henrikh Mkhitaryan is out for six weeks after fracturing his metatarsal, while Nacho Monreal (hamstring) and Shkodran Mustafi are doubts for the visitors' trip to the south-coast.
Laurent Koscielny is expected to be available after being rested for the win over Burnley.
But Hector Bellerin (calf), Kostas Mavropanos (groin) and Emile Smith-Rowe (hip) are out, while Rob Holding (knee) and Danny Welbeck (ankle) are both long-term casualties.
Brighton have won their last three top-flight home matches against Arsenal, after losing the first two meetings.
Arsenal have kept a clean sheet in six of their 10 Premier League matches against Brighton, conceding only six goals in total in this run.
The Gunners have lost only one of their last nine league matches played on Boxing Day, being beaten 4-0 by Southampton in 2015/16.
Glenn Murray has scored two goals in 125 minutes played against Arsenal in all competitions, including the winner for the Seagulls in this fixture last season.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Kevin Friend