Pierre-Emerick Aubameyang (£11.2m) can reward his ever-growing legion of Fantasy Premier League owners as the outstanding captain candidate for Gameweek 16.
That has made Aubameyang the most-bought player for the second successive Gameweek.
After more than 525,000 managers signed him for his midweek trip to Manchester United, another 230,000 have drafted him ahead of the 8 December, 12:30 GMT deadline.
His fellow forward Alexandre Lacazette (£9.6m) can also profit against the Terriers.
The Frenchman is expected to start after featuring as a substitute in the last two Gameweeks.
He has scored or assisted in nine of his 14 appearances.
Kane has found the net in four of the last five Gameweeks and has an eye-catching record against the Foxes, scoring seven goals in their last three Premier League meetings.
The Egyptian is set to return to the Liverpool starting XI after earning minutes off the bench in midweek.
Away from home, Salah’s totals of 28 shots and 12 shots on target both rank second among all players.
Both have recorded two sets of double-figure returns at Goodison Park and host a Watford defence with just one clean sheet in seven road trips.
Ben Crabtree (@FC_CrabDogg): I may leave it on Kane but the Lacazette fixture looks great, too. I think he'll start but would like confirmation before considering him. Sead Kolasinac (£4.9m) is even a little tempting.
Holly Shand (@FFCommunity_): I'm choosing between Kane and Salah. It’s very difficult to split this pair on away form and opposition defensive quality, although Salah might just edge it after his limited minutes in midweek. Aubameyang looks the go-to option if you have him but, after a string of starts, is it his turn on the bench?
Ash (@FPLHints): Rotation could still be an issue this weekend but I can't look beyond Aubameyang as the must-have captain pick, especially with him being the current league top scorer.
Sam Bonfield (@FPLFamily): I'm very tempted to leave the armband on Kane this weekend, although Leicester haven't shipped many goals lately. Salah is another big option, as is Felipe Anderson (£7.2m), who has a nice fixture at home to Crystal Palace. He'll be increasingly important for West Ham United now that Marko Arnautovic (£7.1m) is out injured.
Part 1: GW16 Ones to watch: Back Lacazette to start and star
Part 2: GW16 Differentials: Andone can extend scoring run
Part 4: GW16 Selection: Anderson backed to deliver
Part 5: GW16 Team news: Salah and Sterling set for recalls