Manchester United are looking for a first victory in five Premier League matches as they host Fulham, who are seeking to move off the foot of the table.
Manchester United have doubts over the fitness of Anthony Martial, Chris Smalling, Phil Jones and Luke Shaw.
Victor Lindelof and Alexis Sanchez are expected to miss the match but Ashley Young is available again after suspension.
Fulham duo Kevin McDonald (hamstring) and Floyd Ayite (groin) are expected to be available.
Man Utd have won 21 of their last 23 home matches against Fulham in all competitions, with their only defeat in this sequence coming in the PL in October 2003.
United have made 46 changes to their starting XI this season, including seven in their midweek draw with Arsenal - more than any other PL side.
Fulham are winless in 10 PL away matches and have lost their last six in a row. They last lost more consecutive away fixtures in the competition in March 2006, with eight.
Claudio Ranieri could become only the third manager to win a PL away match at Old Trafford with two different clubs, after Martin O'Neill and Rafael Benitez.
Referee: Lee Probert
Assistants: Adrian Holmes, Andy Garratt
Fourth official: Mike Dean