Cardiff City are seeking a fourth victory in five home matches, while Southampton are looking for their first win in 12 Premier League outings as they begin life under Ralph Hasenhuttl.
Team news
Cardiff City forwards Danny Ward and Kenneth Zohore are set to miss out through injury and Gary Madine is doubtful.
Defender Jazz Richards is also ruled out.
Southampton have midfielder Mario Lemina available again after suspension.
Danny Ings and Ryan Bertrand could feature after recovering from injuries but Michael Obafemi is a doubt.
Did you know?
Cardiff have come from behind to win their last two PL home matches. Only twice has a club ever done so in three consecutive home fixtures: Blackburn Rovers in November 2009 and Newcastle United in March 2013.
Neil Warnock has lost his last three league matches against Southampton, doing so in April 2009 and December 2014 with Crystal Palace and in March 2012 with Leeds United.
Southampton's new manager Ralph Hasenhuttl will be the PL's first Austrian manager. None of the last seven permanent Saints managers have won their first PL match in charge. Paul Sturrock was the last to do so, against Liverpool in March 2004.
Charlie Austin has been involved in nine goals in nine PL starts against promoted sides, with eight strikes and one assist.
Referee: Jonathan Moss
Assistants: Harry Lennard, Andy Halliday
Fourth official: Graham Scott