Wolverhampton Wanderers can extend their unbeaten run in the PL to six matches.
Crystal Palace will be hoping to bounce back from Monday night's defeat at AFC Bournemouth, their fourth loss in six league fixtures.
Crystal Palace striker Christian Benteke is making good progress in his recovery from a knee injury but is not available for the weekend.
Scott Dann and Connor Wickham (both knee) remain sidelined while Jairo Riedewald returned to training this week after missing the match at AFC Bournemouth.
Nuno Espirito Santo has a fully fit Wolverhampton Wanderers squad to choose from, with Ivan Cavaleiro pushing for a first start of 2018/19 after scoring on his PL debut as a substitute.
This will be the first Premier League meeting between Crystal Palace and Wolverhampton Wanderers and their first top-flight match since January 1981.
Wolves are more dangerous after the break, scoring a league-high 88 per cent of their Premier League goals in the second half of matches this season (seven goals out of eight).
Crystal Palace have yet to score at home this term, despite attempting 44 shots, the same as Arsenal who have seven goals.
If Wolves score, there is a 50/50 chance that Raul Jimenez will be involved. The Mexican has been directly involved in half of Wolves' eight Premier League goals this season, with two goals and two assists.
Referee: Michael Oliver
Assistants: Stuart Burt, Simon Bennett
Fourth official: Roger East