Tottenham Hotspur will be hoping to bounce after defeat at Watford last time out, while Liverpool can extend their perfect start to the season.
Tottenham Hotspur will be without Dele Alli (hamstring), and it has emerged that goalkeeper Hugo Lloris (thigh) will be sidelined for a number of weeks.
Son Heung-min is back from winning gold at the Asian Games, but it remains unclear whether or not he will start.
Defender Juan Foyth (thigh) returned to training last week, while midfielder Moussa Sissoko is expected to do so next week.
Liverpool goalkeeper Simon Mignolet (finger) is available but midfielder Adam Lallana (groin) is out.
Alex Oxlade-Chamberlain (knee) remains a long-term injury absentee and Dejan Lovren (stomach) is still not available.
If three goals are scored on Saturday, this will become the Premier League's highest-scoring fixture, overtaking the 151 goals scored in matches between Arsenal and Everton.
Matches featuring these two teams have had 22 penalties, more than any other in the competition's history.
Liverpool's Mohamed Salah has a great record against Spurs, scoring all three of Liverpool's Premier League goals against them last season.
Harry Kane also enjoys this fixture. The Spurs striker has been directly involved in seven goals in seven Premier League appearances against Liverpool, scoring five and assisting two, including four in the last two matches.
Referee: Michael Oliver
Assistants: Stuart Burt, Simon Bennett
Fourth official: Kevin Friend