Ahead of Matchweek 2's fixtures, here are some facts to know for each match.
Click on the fixtures to see head-to-head records, past meetings and form guides.
Saturday, 18 August
Cardiff City v Newcastle United
Rafael Benitez has never lost to Neil Warnock in five previous meetings in all competitions. He has won each of the last four contests since a 1-1 draw between Sheffield United and Liverpool on the opening day of the 2006/07 season.
Everton v Southampton
Southampton’s Charlie Austin has scored three goals for the club in his three Premier League appearances against Everton, but all of these have come in home matches.
Leicester City v Wolves
Leicester v Wolves is one of only four matches in PL history where a team have come from three goals down to win, with Wolves doing so at Molineux in October 2003 despite trailing 3-0 at half-time.
Tottenham Hotspur v Fulham
Spurs are on a run of 18 consecutive home PL victories against promoted opponents.
West Ham v AFC Bournemouth
In five of the six PL matches between West Ham and AFC Bournemouth both teams have scored, with the exception of a 1-0 win for West Ham in August 2016, the first league match at the London Stadium.
Chelsea v Arsenal
Arsenal and Chelsea have met 52 times in the Premier League. In the first 26 meetings, Arsenal had a 54 per cent win rate (W14 D9 L3), while Chelsea have won 54 per cent of the last 26 (W14 D7 L5).
Sunday, 12 August
Burnley v Watford
Burnley have won three of their four PL matches with Watford (L1), including both matches last season.
Man City v Huddersfield Town
With their 0-0 draw at the Etihad Stadium in May, Huddersfield Town were the only side to stop Pep Guardiola’s Man City scoring at home in the Premier League last season.
Brighton & Hove Albion v Man Utd
Brighton were unbeaten in their four home PL matches played on a Sunday last season (W2 D2), while Man Utd have lost four of their last five away league matches played on Sunday (W1).
Monday, 20 August
Crystal Palace v Liverpool
Wilfried Zaha needs one more goal to become Crystal Palace’s all-time highest PL goalscorer. He is currently on 23, level with Chris Armstrong.