Chelsea will visit 2017/18 high flyers Southampton in the first match of their Under-18 Premier League title defence, after the fixtures were released.
Last season, Chelsea won the U18 Premier League national title for the second year running when they beat North Division winners Manchester United 3-0 in the final.
Saints finished third in the South Division, two places and 12 points behind the Blues, and their meeting at Staplewood Training Ground is one of 11 matches on Saturday 11 August, the opening day of the 2018/19 campaign.
Man Utd host Derby County, while 2015/16 champions Manchester City entertain Newcastle United.
Elsewhere, Everton's U18s play Wolverhampton Wanderers on the same day their senior teams meet in their Premier League opener, while last season's South Division runners-up Arsenal host Aston Villa.
See: All 2018/19 U18 Premier League fixtures
Matchweek 1 fixtures
Saturday, 11 August 2018
North Division
11:00 Stoke City v Blackburn
11:30 Everton v Wolves
12:00 Man Utd v Derby
12:30 Man City v Newcastle
13:00 Sunderland v Liverpool
South Division
11:00 Fulham v Swansea City
11:00 Southampton v Chelsea
11:30 Spurs v Brighton
12:00 Arsenal v Aston Villa
12:00 Leicester City v Reading
12:00 Norwich City v West Ham
*Kick-off times BST, fixtures subject to change