Mousa Dembele (ankle), Serge Aurier (hamstring) and Eric Dier (illness) will be assessed to determine if they can return.
Kieran Trippier (knee) and Victor Wanyama (thigh) will also be checked on after coming off against Newcastle United. Harry Winks continues his rehabilitation from a long-term ankle problem.
Leicester City are certainly without Robert Huth, Shinji Okazaki, Ben Chilwell (all ankle), Daniel Amartey, Wilfred Ndidi (both thigh), Matty James (Achilles) and Marc Albrighton (suspended).
Kasper Schmeichel (ankle) is a major doubt and Aleksandar Dragovic (shoulder) and Danny Simpson (groin) will also need to be assessed.
Adrien Silva and Fousseni Diabate are expected to be available despite minor problems.
Did you know?
Leicester City, who won November's reverse fixture 2-1, will be aiming to complete a league double over Tottenham Hotspur for the first time since 1998/99.
The Foxes will also be targeting their first win in seven PL trips to London. When they last visited the capital they lost 5-0 at Crystal Palace.
Spurs are guaranteed a top-four finish for the third consecutive PL season. It’s the first time they've had three top-flight finishes of fourth or higher since a run of five campaigns between 1959/60 and 1963/64.
Against no side has Harry Kane scored more PL goals than he has versus Leicester City, nine, level with Stoke City.
Club previews
Tottenham Hotspur: "Finishing in the top four is a massive achievement"
Leicester City: Puel's fitness update in full
Referee: Craig Pawson
Assistants: Stuart Burt, Simon Beck
Fourth official: David Coote
